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HIV strain matters for treating new cases

The specific strain of HIV that a person first contracts can have a lasting impact on how the virus disrupts his or her immune system, say researchers.

“This may have important implications for cure strategies aimed at eliminating the viral reservoir, as individuals infected with low replicat... Read More

Gut Bacteria Byproduct Linked to Chronic Kidney Disease for the First Time

Cleveland Clinic researchers have, for the first time, linked trimethylamine N-oxide (TMAO) – a gut metabolite formed during the digestion of egg-, red meat- or dairy-derived nutrients choline and carnitine – to chronic kidney disease.

TMAO has been linked to heart disease already, with blood... Read More

TWiP 82 letters


Allan writes:


Dear Vincent, Dickson and Daniel,


I like your idea of a TWIP coffee mug prize (or maybe a mug discount).


In this second case study you presented, the present symptoms are pretty vague, but his history is interesting. Also since with ... Read More

Oil Eating Microbes Have Worldwide Underground Connections

Living deep underground ain't easy. In addition to hellish temperatures and pressures, there's not a lot to eat. Which is why oil reservoirs are the microbes’ cornucopia in this hidden realm.

Microbes feast on many oil reservoirs, but it has been unclear how the micro-organisms got to those ... Read More

TWiV 323: A skid loader full of viromes

Hosts: Vincent RacanielloDickson DespommierAlan Dove, Read More

Mothers can pass traits to offspring through bacteria’s DNA

It’s a firmly established fact straight from Biology 101: Traits such as eye color and height are passed from one generation to the next through the parents’ DNA.

But now, a new study in mice by researchers at Washington University School of Medicine in St. Louis has shown that the DNA of ba... Read More

TWiM 97 Letters


Dennis writes:
hi Doc,


A paper just published in nature:


http://www.nature.com/nature/journal/vaop/ncurrent/pdf/nature14098.pdf


reports an effective antibiot... Read More

Why we haven't eradicated the plague

More than 600 years after the bubonic plague wiped out about half of Europe, scientists still don’t fully understand how bacteria that cause the disease travel from the site of a fleabite to the lymph nodes, where the rampage truly begins.

Researchers who’ve been studying the bacteria say the... Read More

Virus-cutting enzyme helps bacteria remember a threat

Bacteria may not have brains, but they do have memories, at least when it comes to viruses that attack them. Many bacteria have a molecular immune system which allows these microbes to capture and retain pieces of viral DNA that they have encountered in the past, in order to recognize and destro... Read More

The Forgotten Plague, Chapter 1(video)

By the dawn of the 19th century, tuberculosis had killed one in seven of all people that had ever lived. Doctors believed it was hereditary, but had begun to observe that fresh air and outdoor living could sometimes change the course of the illness. Physician and TB patient Edward Trudeau was co... Read More

A Beautiful Wallpaper Made With Smallpox Vaccine

We’re in the midst of an outbreak of debate, people arguing the merits of vaccinations. Its symptoms include feverish rhetoric and noxious op-eds. In an attempt to stem the spread of unhealthy attitudes toward science and misinformation about vaccines, the Bill & Melinda Gates Foundation sponsor... Read More

Live bacterium depicted using X-ray laser

An international team led by Uppsala University scientists has succeeded, for the first time, in depicting intact live bacteria with an X-ray laser. This technique, now described in the journal Nature Communications, can give researchers a clearer understanding of the complex world of cells.

... Read More

Drug targeting ebola virus protein VP24 shows promise in monkeys

An experimental medication that targets a protein in Ebola virus called VP24 protected 75% of a group of monkeys that were studied from Ebola virus infection, according to new research conducted by the U.S. Army, in collaboration with Sarepta Therapeutics, Inc. The study was published this week ... Read More

First results from an Oxford University trial of an Ebola vaccine (video)

A trial of a GSK/NIH candidate Ebola vaccine at Oxford University suggests the vaccine has an acceptable safety profile and is able to generate an immune response.
Read More

Lyme disease costs up to $1.3 billion per year to treat, study finds

Lyme disease, transmitted by a bite from a tick infected by the Borrelia burgdorferi bacteria, had long been considered easy to treat, usually requiring a single doctor's visit and a few weeks of antibiotics for most people.

But new research from the Johns Hopkins Bloomberg School of Public H... Read More

Researchers discover critical molecule in fight against lung infection

A Montana State University graduate student who wants to reduce the number of people dying from lung infections has discovered a molecule that's critical for immunity.

Caffrey researches the early immune response against Aspergillus fumigatus, a common mold that can be found in soil or compos... Read More

Fecal transplants may up risk of obesity onset

Fecal microbiota transplantation can be effective for recurrent Clostridium difficile infection, but new-onset obesity could follow transplant of stool from an overweight donor, a new study finds

"Fecal transplant has helped a lot of people who have run out of other options," Dr. Colleen R. K... Read More

When strep throat is something else: Forgotten bacterium is the cause of many severe sore throats in young adults

New research from the University of Alabama at Birmingham suggests that Fusobacterium necrophorum more often causes severe sore throats in young adults than streptococcus — the cause of the much better known strep throat. The findings, published today in the Annals of Internal Medicine, suggest ... Read More

Interview of Dr. Vincent Racaniello - Journey with Virus

Dr. Vincent Racaniello is the Higgins Professor of Microbiology and Immunology at the college of Physicians and Surgions of Columbia University. Along with his academic research, he is known for expanding knowledge with great contributions through his virology blog virology.ws, and his wide podc... Read More

PhatoMap of New York Subway System

The microbes that call the New York City subway system home are mostly harmless, but include samples of disease-causing bacteria that are resistant to drugs — and even DNA fragments associated with anthrax and Bubonic plague — according to a citywide microbiome map published today by Weill Corne... Read More
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