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Discovery points to a new path toward a universal flu vaccine

Flu vaccines can be something of a shot in the dark. Not only must they be given yearly, there's no guarantee the strains against which they protect will be the ones circulating once the season arrives. Read More

Early HIV treatment improves survival in some patients with newly diagnosed TB

PITTSBURGH, July 9, 2015 - Starting anti-HIV treatment within two weeks of the diagnosis of tuberculosis, or TB, improved survival among patients with both infections who had very low immune-cell counts, according to an analysis by researchers at the University of Pittsburgh Graduate School of H... Read More

Genetic differences may help explain inconsistent effectiveness of anti-HIV drug

Research with human tissue and cells suggests that genetic variations, in addition to failure to comply with treatment regimens, may account for some failures of an anti-HIV drug to treat and prevent HIV infection. Read More

BacterioFiles 221 - Co-culture Close Contact, Cats, and Cockerels

This episode: More distantly related bacteria can help each other grow (and produce lots of hydrogen) by temporarily fusing with each other!


(12.7 MB, 13.9 minutes)


Show notes: 
Read More

TWiV 345: How a vaccine got the nod

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and  Read More

Scripps research-designed drug candidate significantly reduces HIV reactivation rate

HIV-infected patients remain on antiretroviral therapy for life because the virus survives over the long-term in infected dormant cells. Interruption of current types of antiretroviral therapy results in a rebound of the virus and clinical progression to AIDS. Read More

Towards an HIV vaccine

Neutralizing antibodies (Nabs) are immune proteins that recognize, bind to, and trigger the elimination of virus before it can establish a chronic infection. How to elicit a potent Nab response capable of protecting against different HIV subtypes and against different modes of infection is criti... Read More

Researchers identify cause of heart damage in sepsis patients

Researchers at the University of Liverpool's Institute of Infection and Global Health (IGH) have discovered a common cause of heart damage in patients with sepsis.

Sepsis is the most common cause of death in hospitalised critically ill people and affects up to 18 million people world-wide ann... Read More

Newton Fund grant to aid researchers in tackling infectious disease in Malaysia

A group of collaborators led by the University of Southampton have been awarded a British Council Newton Fund Institutional Links Grant to support ground-breaking research towards reducing the burden of infectious disease in Malaysia. Read More

TWiM #107: The battle in your bladder

Vincent and Michael discuss the highly diverse microbiome of uncontacted Amerindians, and how the composition of human urine plays a role in the bat... Read More

TWiM 107 Letters

Jim writes:


Hi Vince,
For your interest in listening to physics, there is a podcast called The Titanium Physicists Podcast. They use a conversational format similar to what you use. They have a panel of experts and a guest who is not a physicist but who is accom... Read More

The sting in dengue's tail

In a new Science study, Duke-NUS Graduate Medical School Singapore (Duke-NUS) scientists have identified how small changes in dengue's viral genome can affect the virus' ability to manipulate human immune defences and spread more efficiently. This research is the first of its kind that examined ... Read More

Researchers develop world's most sensitive test to detect infectious disease, superbugs

Infectious diseases such as hepatitis C and some of the world's deadliest superbugs--C. difficile and MRSA among them--could soon be detected much earlier by a unique diagnostic test, designed to easily and quickly identify dangerous pathogens. Read More

Felinine Plays a Role in the Chasing and Fighting between Cats and Mice

A recent study found that mice may be controlled to be brave in the fight with their biggest enemy cats after smelling a chemical emitted by them and existed in their urine. Read More

The next anti-tuberculosis drug may already be in your local pharmacy

Testing thousands of approved drugs, EPFL scientists have identified an unlikely anti-tuberculosis drug: the over-the-counter antacid lansoprazole (Prevacid®). Read More

Study identifies new way to kill the malaria parasite

Scientists have discovered new ways in which the malaria parasite survives in the blood stream of its victims, a discovery that could pave the way to new treatments for the disease.

The researchers at the Medical Research Council's (MRC) Toxicology Unit based at the University of Leicester an... Read More

The Wall of Polio, version 3.0

Back in 2013 I built a Wall of Polio in my laboratory – a large stack of six-well cell culture plates that have been used to measure the concentration of polioviruses in various samples by plaque assay. It became a focal point of the lab at which many guests came to have their photographs taken.... Read More

Stopping Candida in its tracks

Scientists are one step closer to understanding how a normally harmless fungus changes to become a deadly infectious agent. Read More

Safer, with more benefits: Parents' vaccine views shifting

ANN ARBOR, Mich. -- Over the same time period that multiple outbreaks of measles and whooping cough made headlines around the country, parents' views on vaccines became more favorable, according to a new nationally-representative poll. Read More

BacterioFiles 220 - Coliforms Cooperate by Conduit

This episode: Bacteria can connect to each other with tiny tubes to exchange nutrients!


(10 MB, 10.9 minutes)


Show notes: 
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