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Research on new, rapid screening test identifies potential therapies against drug-resistant bacteria

Researchers at the National Institutes of Health’s National Center for Advancing Translational Sciences (NCATS), Clinical Center and National Institute of Allergy and Infectious Diseases (NIAID) have created a new way to identify drugs and drug combinations that may potentially be useful in comb... Read More

Study Links Antibiotic Resistance with Exposure to the Disinfectant Chlorhexidine

Klebsiella pneumoniae bacteria exposed to chlorhexidine-containing disinfectants can become resistant to colistin, a last resort antibiotic often used against multidrug resistant pathogens. This is the first study to link exposure to chlorhexidine with resistance to colistin in this clinically i... Read More

Engineers design programmable RNA vaccines

CAMBRIDGE, MA -- MIT engineers have developed a new type of easily customizable vaccine that can be manufactured in one week, allowing it to be rapidly deployed in response to disease outbreaks. So far, they have designed vaccines against Ebola, H1N1 influenza, and Toxoplasma gondii (a relative ... Read More

TWiV 438: Drs. TWiV go to Washington

On the eve of the March for Science, the TWiV team gathers at ASM Headquarters in Washington, DC with guests Stefano and Susie to talk about the state of science communication.


Hosts: Vincent Racaniello... Read More

Mcr-1 Gene Isolated from Human for the First Time in Brazil

Washington, DC – August 8, 2016 – For the first time in Brazil, a particular antibiotic resistance mechanism conferring resistance to the important antibiotic, colistin, has been detected in a human. It was in a strain of Escherichia coli that was isolated from a diabetic patient’s foot infectio... Read More

Self-Prescribing Antibiotics is a Big Problem

Washington, DC – July 11, 2016 - Five percent of adults from a cohort of 400 people reported using antibiotics without a prescription during the previous 12 months. Twenty-five percent said they would use antibiotics without contacting a medical professional. These findings demonstrate yet anoth... Read More

Computer Model Is ‘Crystal Ball’ for E. Coli Bacteria

It’s difficult to make predictions, especially about the future, and even more so when they involve the reactions of living cells — huge numbers of genes, proteins and enzymes, embedded in complex pathways and feedback loops. Yet researchers at the University of California, Davis, Genome Center ... Read More

Antibiotic Resistance Appears to Persist in Bacteria, Even Absent Selection Pressure From Antibiotics

Washington, DC – August 1, 2016 – Plasmids are pieces of independent DNA that often carry multiple antibiotic resistance genes. Plasmids can jump from one bacterium to another, spreading that resistance. A team of French investigators now shows that bacteria that acquire plasmids containing res... Read More

BacterioFiles 282 - Mycobacteria Make Mice Mellow

This episode: Vaccinating mice with heat-killed soil bacteria reduced their stressed behavior and inflammation!


(9.8 MB, 10.7 minutes)


Show notes: 


Journal Paper:

Reber SO, Siebler PH, Donner NC, Morton JT, Smith ... Read More

Gut bacteria imbalance increases diabetes risk

Currently, scientists think the major contributors to insulin resistance are excess weight and physical inactivity, yet ground-breaking new research by an EU funded European-Chinese team of investigators called MetaHit have discovered that specific imbalances in the gut bacteria can cause insuli... Read More

Virus communication system discovered

Bacteria can communicate through a system known as quorum sensing, where, for example the production of toxin in some species is not initiated until a minimum threshold of bacterial cells are present. This allows them to coordinate and therefore strengthen their actions to overcome selective pre... Read More

Additives to Boost Vaccine Responses Not Sufficient to Protect Obese Mice From Influenza

Washington, DC – August 2, 2016 – Adjuvants – ingredients added to vaccinations for influenza and other viruses to help boost their effectiveness – can increase a host’s immune response but not enough to protect the obese against the ill effects of the flu, according to a mouse study published t... Read More

Examining Aspergillus fumagatus on the Space Station

As the durations of manned space missions increase, it is vitally important to understand the long-term consequences of microbial exposure on human health in closed human habitats. One mission of the Microbial Observatory Experiments on the International Space Station is to examine the traits an... Read More

Designer bacteria build carbon-silicon materials for the first time

Scientists have genetically engineered bacteria to make a protein that squishes silicon and carbon together long enough for them to stick to one another — forming a bond that, until now, only chemists had managed to create. If scientists can teach these bacteria to produce the carbon-silicon mol... Read More

Maybe they're born with it: intrinsic antibiotic resistance

Several recently published mBio studies describe new mechanisms of intrinsic antibiotic resistance. These mechanisms may themselves become therapeutic targets to broaden the application of currently available drugs. Read More

Science Magazine: New antibiotic found in human nose

With drug-resistant bacteria on the rise, scientists believe the nose is engaging in "microbial warfare". Scientists in Germany have identified that Staphylococcus lugdunensis, found in the nose, excretes a compound they named lugdunin. This compound prevents S. aureus from growing. S. aureus ca... Read More

Heater-cooler devices blamed for global Mycobacterium chimaera outbreak

A global outbreak of Mycobacterium chimaera, an invasive, slow-growing bacterium, is linked to heater-cooler devices (HCD) used in cardiac surgery, according to a study published today in Infection Control & Hospital Epidemiology, the journal of the Society for Healthcare Epidemiology of Americ... Read More

Pre-cut Salad May Encourage Growth of Salmonella

Washington, DC – November 18, 2016 – A new study from the University of Leicester shows that small amounts of damage to salad leaves in bagged salads encourage the presence of Salmonella enterica. Juices released from damaged leaves also enhance the pathogen’s ability to attach to the salad’s pl... Read More

First evidence that GM mosquitoes reduce disease

Releasing genetically modified mosquitoes appears to have helped reduce cases of dengue in a town in Brazil. The news comes as the US is considering whether to approve the use of the same mosquitoes.

The trial involved Aedes mosquitoes that had been modified to kill off wild mosquitoes of the... Read More

Simple food additive slows E. coli food poisoning

Polysorbate, a safe additive found in everything from ice cream to cosmetics, has been proven to slow the toxic effects of E. coli poisoning.

Had this discovery been known before the deadly 2011 E. coli outbreak in Germany, doctors may have had one more tool to save some of victims.

The fi... Read More
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