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A system‐level model for the microbial regulatory genome

Microbes can tailor transcriptional responses to diverse environmental challenges despite having streamlined genomes and a limited number of regulators. We present data‐driven models that capture the dynamic interplay of the environment and genome‐encoded regulatory programs of two types of prok... Read More

TWiV 294: Smallpox and anthrax and flu, oh my!

The TWiV team reviews the discovery of old vials of smallpox virus at NIH, anthrax and influenza mishaps at CDC, the baby who was not cured of HIV, Cambridge Working Group, and sacking of NSABB members.


Hosts:  Read More

TWiP 75: Parasite wonders with Bobbi Pritt

Bobbi Pritt joins Vincent and Dickson to talk about directing a clinical parasitology laboratory and her weekly case reports at Creepy Dreadful Wonderful Parasites.


Hosts: Vincent Racaniello and  Read More

The unseen power of microbes - Ozgur Sahin, Ph.D (video)

This talk was given at a local TEDx event, produced independently of the TED Conferences. How can we possibly harness evaporation and say, run the engine of a car, lift heavy weights, and generate electricity? While investigating the mysterious wrinkles seen in the protective coats of bacterial ... Read More

First local case of tropical disease chikungunya debuts in the U.S.

The day we knew would come is finally here. The first locally acquired case of the tropical disease chikungunya was reported in the U.S. today.

The mosquito-borne viral disease first debuted in the Western Hemisphere last year and has since sprawled across the Caribbean, with cases in Puerto ... Read More

Scientists find way to trap, kill malaria parasite

Scientists may be able to entomb the malaria parasite in a prison of its own making, researchers report. As it invades a red blood cell, the malaria parasite takes part of the host cell's membrane to build a protective compartment. The parasite then starts a series of major renovations that tran... Read More

Meet the electric life forms that live on pure energy

Unlike any other life on Earth, these extraordinary bacteria use energy in its purest form – they eat and breathe electrons – and they are everywhere

STICK an electrode in the ground, pump electrons down it, and they will come: living cells that eat electricity. We have known bacteria to surv... Read More

Modified Ziehl Neelsen Stained Cyclospora cayetanensis

HI, I am Dinesh Bhandari.
I am a thesis year student of Msc. medical microbiology from Tri-Chandra campus Nepal. Currently I am doing my research in Cryptosporidium parvum and Cyclospora cayetanensis infection among School children of kathmandu at Public health research laboratory, the Institu... Read More

Poor Oversight Catches Up with High-Security Infectious Agent and Disease Labs

The Centers for Disease Control plans to take measures to better protect lab workers and the rest of us from dangerous biological samples.

Twenty-one dead lab chickens piled up this spring at a government facility before its researchers could pinpoint why. The team had requested and received ... Read More

The U.S. Neglects Its Best Science Students

The U.S. education policy world—the entire country, for that matter—is on a quest to increase the ranks of future innovators in science and technology. Yet the programs that get funded in K–12 education do not support students who are already good at and in love with science. These students have... Read More

‘Tis the Season to be Sweating

This is the time of the year of increased physical activity when we pay special attention to certain parts of the body, including the armpit. As is usually the case, our microbiota is involved because the odor associated with sweating is produced by microbial activity. The main culprits are skin... Read More

Choosing cheese: Research identifies microbial communities in cheese

After studying 137 varieties of cheese collected in 10 different countries, researchers have been able to identify three general types of microbial communities that live on cheese, opening the door to using each as a 'model' community for the study of whether and how various microbes and fungi c... Read More

GW Researcher Unlocks Next Step in Creating HIV-1 Immunotherapy Using Fossil Virus

The road to finding a cure for HIV-1 is not without obstacles. However, thanks to cutting-edge research by Douglas Nixon, M.D., Ph.D., and colleagues, performed at the George Washington University (GW), Oregon Health & Science University, the University of Rochester, and UC San Francisco, the sc... Read More

Oregon geologist says Curiosity's images show Earth-like soils on Mars

Soil deep in a crater dating to some 3.7 billion years ago contains evidence that Mars was once much warmer and wetter, says University of Oregon geologist Gregory Retallack, based on images and data captured by the rover Curiosity.

NASA rovers have shown Martian landscapes littered with loos... Read More

When the Microbe Hits the Metal

Some heavy metals share a long history with microbes. Many of the metabolic processes that sustain life are believed to have originated from spontaneous reactions involving metals present in the early Earth. Our microbial ancestors figured out quickly how to use those metal catalysts to generate... Read More

Molecular Computer Detects Ebola and Marburg Viruses

Material from deadly pathogens triggers alerts directly, and could speed detection. Early detection is key to slowing outbreaks of Ebola, such as the one currently spreading across west Africa that is estimated to have infected almost 1000 people, according to the latest World Health Organizatio... Read More

TWiP 75 letters


David writes (re lice and iron):


All I remember that I know is that one time I let my cat endure a heavy flea infestation for an unconscionably long time. I redeemed myself, if at all, by the knowledge that I slept with her a lot, and so endured a share myself (b... Read More

Methyl Red/Vogoes-Proskauer (MR-VP)

Methyl Red/Vogoes-Proskauer (MR-VP)
One medium used for two separate but related tests, identifying butanediol (VP) or acidic fermentation products (MR) as part of the IMViC test used in the identification of Enterobacteriaceae.

•Methyl Red (MR): detects the ability of an organism to produc... Read More

ULTRASMALL BACTERIA FROM ANTARCTIC LAKE RAISE QUESTIONS ABOUT THE LIMITS OF LIFE

Imagine you were forced to live in perpetually subzero temperatures, with no oxygen, no light, and way more salt than your system could handle. How would you manage? One way might be to get extremely small. At least, that seems to be what’s happening in a frozen Antarctic lake that’s cut off fro... Read More

Urease: an anti-microbial target in bacteria and fungi

Urea is a small molecule formed as proteins are broken down. It’s excreted in urine, but isn’t particularly toxic at low levels so it’s found in cells throughout the body. The molecular structure of urea is below, and as it contains nitrogen (N) several pathogens have adapted to use it as a nitr... Read More
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