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How immunity to RSV develops in childhood but deteriorates in adults

The leading infectious cause of severe respiratory disease in infants, respiratory syncytial virus (RSV), is also a major cause of respiratory illness in the elderly. Approved vaccines do not yet exist, and despite the development of partial immunity following infection during childhood, individ... Read More

UC San Diego scientists receive $9.5 million NIH grant to combat antibiotic resistance

Researchers at University of California, San Diego School of Medicine have received a five-year, $9.5-million award from the National Institute of Allergy and Infectious Diseases at the National Institutes of Health (NIH) to establish an interdisciplinary center to define the systems biology of ... Read More

Structure of Zika virus determined

A near-atomic level map of Zika virus shows its structure to be largely similar to that of dengue virus and other flaviviruses, but with a notable difference in one key surface protein, report scientists funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the Nat... Read More

Wealth of unsuspected new microbes expands tree of life

Researchers at the University of California, Berkeley, who have discovered more than 1,000 new types of bacteria and Archaea over the past 15 years lurking in Earth's nooks and crannies, have dramatically rejiggered the tree to account for these microscopic new life forms. Read More

SOME FROGS ARE EVOLVING TO SURVIVE A KILLER FUNGUS

As reported in a new study in the the journal Proceedings of Royal Society B: Biological Sciences, scientists have taken a step toward identifying the genetic mechanisms that makes some lowland leopard frogs in Arizona resistant to Batrachochrytrium dendrobatridis (Bd) infections that cause the ... Read More

Researcher pioneers bacterial infection treatment using novel target: Vesicles

Bacterial infection takes hold in the body when a pathogenic microorganism delivers toxins to healthy cells. One way bacteria accomplish this is by releasing vesicles, which act as tiny envelopes transporting toxins and other virulence factors to host cells. These toxins allow the bacteria to "m... Read More

Why neural stem cells may be vulnerable to Zika infection

Zika's hypothesized attraction to human neural stem cells may come from its ability to hijack a protein found on the surface of these cells, using it as an entryway to infection. In Cell Stem Cell on March 30, researchers at the University of California, San Francisco show that the AXL surface r... Read More

RESURRECTED DRUG MAY OFFER A WAY TO FIGHT ZIKA, EBOLA

Viruses have proven to be wily foes. Attempts to fend off viruses that cause the common cold or flu have failed, and new viral outbreaks such as dengue, Ebola, or Zika continue to elude drugs.

Given these challenges, scientists are tackling the problem from a different angle. The want to boos... Read More

Your viruses could reveal your travel history, and more

The genomes of two distinct strains of the virus that causes the common lip cold sore, herpes simplex virus type 1 (HSV-1), have been identified within an individual person -- an achievement that could be useful to forensic scientists for tracing a person's history. The research also opens the d... Read More

An ancient killer: Ancestral malarial organisms traced to age of dinosaurs

CORVALLIS, Ore. - A new analysis of the prehistoric origin of malaria suggests that it evolved in insects at least 100 million years ago, and the first vertebrate hosts of this disease were probably reptiles, which at that time would have included the dinosaurs. Read More

Neanderthals may have been infected by diseases carried out of Africa by humans

A new study suggests that Neanderthals across Europe may well have been infected with diseases carried out of Africa by waves of anatomically modern humans, or Homo sapiens. As both were species of hominin, it would have been easier for pathogens to jump populations, say researchers. This might ... Read More

Typhoid toxin increases host survival and promotes asymptomatic infection

Genotoxins damage the genetic material in cells and can cause mutations and cancer. Some bacteria code for and produce genotoxins. A study published on April 7th in PLOS Pathogens reports the surprising finding that one of them, typhoid toxin, actually increases survival of the infected host and... Read More

Pandemic E. coli strain H30 cloaks its stealth strategies

The difficulty in subduing the pandemic strain of drug-resistant E. coli, called H30, may go beyond patient vulnerability or antibiotic resistance. This form of the disease-pathogen may have an intrinsic ability to cause persistent, harmful, even deadly infections. Read More

NIH launches large clinical trials of antibody-based HIV prevention

Enrollment has begun in the first of two multinational clinical trials of an intravenously delivered investigational antibody for preventing HIV infection. Known as the AMP Studies, for antibody-mediated prevention, the trials will test whether giving people an investigational anti-HIV antibody ... Read More

Canadian innovation for killing mosquito eggs could help Zika fight

Toronto, Canada - With Canadian Government funding, a team of innovators from Canada and Mexico have successfully tested a low cost, environmentally-friendly way of destroying the eggs of the mosquito genus that spreads dengue, and likely spreading the Zika virus. Read More

New mouse model to aid testing of Zika vaccine, therapeutics

A research team at Washington University School of Medicine in St. Louis has established a mouse model for testing of vaccines and therapeutics to battle Zika virus. Read More

Structure and genome of Zika virus

Group: Group IV ((+) ssRNA)
Family: Flaviviridae
Genus: Flavivirus
Species: Zika virus

Structure of Zika Virus
•The virion is approximately 40 nm in diameter with surface projections that measure roughly 5-10 nm.
•Nucleocapsid is 25-30 nm in diameter surrounded by a host-membrane derive... Read More

Trophoblasts resistant to Zika/Zika in the mouse

Two unrelated studies on the Zika virus--one ruling out a theory for how Zika may be passing through the human placenta and another on using mouse models to trace Zika pathogenesis--appear April 5 in Cell Host & Microbe. Read More

A nasal mystery

I have had chronic nasal congestion for my whole life. Sometimes it is worse, sometimes it is better, but it is never completely gone. I have seen ENT specialists and have only ever been told that it must be allergies. I have never believed this, and so I have finally taken matters into my own h... Read More

Promising new method inhibits TB-causing bacteria

Scientists at the The University of Queensland and the University of California San Francisco have found a new way to inhibit the growth of the bacterium that causes tuberculosis (TB). Read More
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