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Toxoplasmosis: A T.Gondii Host-pathogen interactome

09/11/2012
This parasite interacts with many host proteins and modifies the expression of many more genes creating an interactome with almost 3000 links. In addition it exchanges substrates and metabolites with the host, modifying many biochemical parameters. T.Gondii disrupts multiple signalling networks and these are recorded in a KEGG ...

Alzheimer's might be transmissible in similar way as infectious prion diseases

10/04/2011
This study, from the University of Texas, injected mice brains with brain tissue from an Alzheimer's disease patient.. The mice developed Alzheimer's disease pathology . This confirms many suspicions concerning a role for infectious agents - for example herpes simplex, as long advocated by Ruth Itzhaki http://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&DbFrom=pubmed&Cmd=Link&LinkName=pubmed_pubmed&IdsFromResult=18328007 or ...

Alzheimer's disease - a neurospirochetosis. Analysis of the evidence following Koch's and Hill's criteria.

08/08/2011
Borrelia burfgdorferi and several oral Treponemas spirochetes were found in Alzheimer's disease brains, and are able to promote beta-amyloid depositiion and tau phosphorylation in vitro. Early detection and eradication could have a marked effect on the development of Alzheimer's disease.(published by Judith Miklossy)

Searching for an effective, safe and universal anti-HIV vaccine: Finding the answer in just one short peptide

07/22/2011
A bioinformatics comparison between HIV-1 viral glycoprotein gp160 revealed 15 pentapeptides highly conserved among a number of retroviral sequences, and absent in the human proteome, thus representing unique molecular retroviral signatures.
07/19/2011
The autoantibodies seen in HIV-1/AIDS target many members of the immune network and the autoantigens are homologous to viral proteins: Antibodies raised to the virus may target the immune system because of this mimicry. See also http://www.polygenicpathways.co.uk/AIDShiv.htm

Genes, malevolent and beneficial pathogens and autoantibodies in HIV-1/AIDS

07/14/2011
Certain viral infections are known to increase or decrease HIV-1 replication or viral load, perhaps by competing with the same receptors, or via immune and other effects.Many autoantibodies in HIV-1 infection also target the immune network and this may well contribute to pathology.

The microbiome: Viruses and pathogens in human diseases

05/15/2011
Viruses, bacteria and other pathogens are implicated in a number of human diseases including Alzheimer's disease, epilepsy, muliple sclerosis and Parkinson's disease, ADHD, autism, bipolar disorder, depression and schizophrenia, arthritis, irritable bowel syndrome, obesity, cancers and many others.Their involvement is listed on this page with outclicks to Pubmed:

KEGG pathway analysis of 1443 HIV-1/host interactions

03/14/2011
There are 1443 host viral interactions in the NCBI database. These were pumped through a KEGG pathway analsis, providing a useful insight into the multiple processes affected by HIV-1 infection. These include life cycle pathways , endocytosis and the like, but also many immune-related pathways and pathways related to HIV-1 ...

Helicobacter pylori: Host/pathogen interactions

03/01/2011
This is a debut that I hope will grow into a larger and more useful database: Any contributions are welcome.

Alzheimer''s disease plaques and tangles: Repositories of a herpes simplex/immune system battle leading to neuronal destruction

12/30/2010
The protein components of the plaques and tangles seen in the Alzheimer's disease brain offer a clue to the origins of the disease: It turns out that they are heavily enriched in human proteins used by herpes simplex during its life cycle: Many immune system related proteins are also found ...

KEGG pathways analysis of the Herpes simplex host viral interactome

11/14/2010
During its life cycle the HSV-1 virus interacts with a large number of host proteins, catalogued at http://www.polygenicpathways.co.uk/herpeshost.html. KEGG pathway analysis of these human proteins reveals the expected types of pathways, including endocytosis, actin related paythways, protein processing etc that are used by the virus during its visits to ...

The human genome is composed of viral DNA II: Individual proteins contain multiple viral inserts

08/24/2010
Individual proteins, and individual translated exons within these proteins, are composed of multiple internested viral protein fragments. This is illustrated for the translated exons of DISC1 , where the different viral contributions are colour coded for each virus or phage.

The human Genome is composed of viral DNA

08/16/2010
Evidence from over 2 million viral/human alignments, shows that the human genome is composed of viral DNA. This is not just retroviruses (XMRV and HIV-1) but common viruses such as the rhinovirus, Epstein-Barr, influenza, herpes, papillomavirus, coronavirus and many more. This supports the idea, proposed over a century ago, by J.B.S.Haldane ...

Environmental Risk factor database: Bugs and Genes II: Alzheimer's , Multiple sclerosis, Parkinson's, Bipolar disoder and Schizophrenia.

08/07/2010
This is a database of environmental risk factors, often viruses, bacteria and parasites, that have been implicated in Alzheimer's disease, Bipolar disorder, Multiple sclerosis, Schizophrenia, and Parkinson's disease , all accessible from the home page. In general the degree of risk conferred by these pathogens is far greater than ...

PolygenicBlog: Bugs and genes

08/07/2010
This is a blog that tries to address the relationships between genes and environmental risk factors , particularly viruses, bacteria and parasites, in some common diseases, including Alzheimer's disease, Bipolar disorder, multiple sclerosis, Schizophrenia and Parkinson's disease and also provides some information on the various pathogens (Herpes, chlamydia, Borrelia, Helicobacter, ...

Herpes simplex: Host Viral interactions database

08/07/2010
This is a database of Herpes simplex (HSV-1) host/viral interactions hosted at WikiGenes. It provides a global snapshot of what the virus does in different compartments at all stages of the viral life-cycle from entry to exit. The database is interactive, and any researcher can edit the page or add ...

XMRV, Chronic Fatigue and prostate cancer

08/06/2010
The XMRV retrovirus has been implicated in chronic fatigue syndrome and prostate cancer. A homology search comparing retroviral with human proteins revealed short contiguous amino acid strings (typically 5-8 aa) matching human proteins whose dysfunction might be expected to cause fatigue, including mitochondrial proteins related to oxidative phosphorylation, glutamate receptors ...

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