A compound from the South African toothbrush tree inactivates a drug target for tuberculosis in a previously unseen way.
Tuberculosis causes more deaths worldwide than any other bacterial disease. At the same time as rates are increasing, resistance strains are emerging due, in part, to non-compliance with the treatment required. Many current drugs are nearly 50 years old and alternatives are needed to the long, demanding treatment schedules. The compound under research, diospyrin, binds to a novel site on a well-known enzyme, called DNA gyrase, and inactivates the enzyme. DNA gyrase is essential for bacteria and plants but is not present in animals or humans. It is established as an effective and safe drug target for antibiotics.
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