Medical Diagnostics: A library of peptides on the surfaces of bacteria can capture new antibodies associated with celiac disease.
Celiac disease, an autoimmune disorder, is notoriously difficult to diagnose, particularly in its early stages. Now, researchers have developed a strategy to capture novel celiac disease antibodies. The technique successfully differentiated between sick and healthy people (Anal. Chem., DOI: 10.1021/ac303201d).
When patients with celiac disease eat wheat or other grains, their misfiring immune systems attack a grain protein called gluten sitting in their intestines, damaging nearby tissue. Immune system proteins called antibodies bind to intestinal tissues, marking them for destruction.
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