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River Monster: The Epidemiology, Ecology, and Pathobiology of Cholera (video)

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John Mekalanos discusses the biology of cholera, driven by his investigations on the molecular genetics of the causative bacterial organism. With his many colleagues in Bangladesh, Haiti, and elsewhere, he has provided strong evidence for how this organism emerged as a human pathogen and has recently become more pathogenic, as well as for why epidemics begin and end so abruptly. He applied this knowledge to the construction of genetically stable cholera vaccines that have been successfully tested in the United States and Bangladesh.

00:00 Introduction by Joan Ruderman, Senior advisor to the science program, Academic Ventures at the Radcliffe Institute and Marion V. Nelson Professor of Cell Biology at Harvard Medical School

01:54 "River Monster: The Epidemiology, Ecology, and Pathobiology of Cholera" by John Mekalanos, the Adele H. Lehman Professor of Microbiology and Molecular Genetics and the head of the Department of Microbiology and Immunobiology, Harvard Medical School

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