The foreground shows the density map (gold) from a cryoelectron micrographic reconstruction of malabaricus grouper nervous necrosis virus, a fish nodavirus. The background shows the fitting of a two-domain model consisting of a protruding domain and a β-sandwich domain into the reconstruction density (semitransparent surface). Three subunits of the T=3 icosahedral lattice are colored in blue, red, and green, respectively. The model was derived from that for tomato bushy stunt virus.
Cover photo June 2002 Journal of Virology.