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Protein folding evolved in knotty puzzle

Protein knots, a structure whose formation remains a mystery, may have specific functional advantages that depend on the nature of the protein’s architecture.

“The presence of a knotted or slipknotted structure in a protein is relatively rare but really is very interesting,” says Kenneth Millett, a professor of mathematics at University of California, Santa Barbara and a co-author of the paper to be published in the Proceedings of the National Academy of Sciences.

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