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To kill cancer, don’t let genes go silent

Researchers have identified a small number of specific genes that need to be silenced for cancer cells to survive.

The discovery—detailed in the May 15 issue of Cancer Cell—means the genes may be good targets for new, more effective treatments.
“We tracked down these genes and it’s the first time that it’s been done,” says Peter Jones, professor of urology, biochemistry, and molecular biology at the University of Southern California (USC) and principal investigator of the study. “If these genes are not silenced through DNA methylation, the cancer cell dies.”

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