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Interferon-inducible transmembrane (IFITM) protein family members potently restrict the replication of multiple pathogenic viruses including influenza viruses

IFITM3 is seen to be essential in defending the host against influenza A virus in vivo. Mice lacking Ifitm3 displayed fulminant viral pneumonia vs. wild type; protection was achieved by re-introduction of Ifitm3. They also found clinical correlation using genotype analysis with influenza virus load. IFITM3 may strongly alter the course of influenza virus infection in mice and humans.

Original Nature Article:
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10921.html
 
 

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