MicrobeWorld App

appsquarebannerad200x200

Microbes After Hours

WaterSupplyYouTubeFrame

Click for more "Microbes After Hours" videos

Join MicrobeWorld

Subscribe via Email

subscribe

Featured Image

Featured Video

Ebola Virus explained

Supporters

ASM House 200X200

Old antibiotic could be a new weapon to fight tuberculosis

Image
TB kills almost 2 million people a year worldwide, and is increasingly becoming resistant to the antibiotics used to treat it, but there are few new drugs in the pipeline. Doxycycline was introduced in 1967 and is used to treat a wide range of bacterial infections, but until now has not been recognized as effective against TB. The new study, published in the American Journal of Respiratory and Critical Care Medicine, suggests that doxycycline might stop the bacteria from growing and also prevent the disease from damaging the lungs.

Last year, researchers at Imperial College London discovered that TB increases the production of an enzyme called MMP-1, and that this enzyme is responsible for destroying lung tissue.

Now they have found that doxycycline suppresses the production of the tissue-destroying enzyme in TB-infected human cells. They also found that doxycycline directly inhibits the growth of the bacteria in guinea pigs ā€“ a surprising result since the drug has been widely used as an antibiotic for over 40 years but has not been considered effective against TB.
 
 

Comments (0)

Collections (0)

 

American Society for Microbiology
2012 1752 N Street, N.W. ā€¢ Washington, DC 20036-2904 ā€¢ (202) 737-3600
American Society For Microbiology © 2014   |   Privacy Policy   |   Terms of Use