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Decoding the molecular machine behind E.coli and cholera

Writing in the journal PLoS Pathogens, the team from Queen Mary’s School of Biological and Chemical Sciences show how they studied the molecular machine known as the ‘type II bacterial secretion system’, which is responsible for delivering potent toxins from bacteria such as enterotoxigenic E. coli and Vibrio cholerae into an infected individual.

Professor Richard Pickersgill, who led the research, said: “Bacterial secretion systems deliver disease causing toxins into host tissue. If we can understand how these machines work, then we can work out how it they might be stopped.”

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