MicrobeWorld App


Join MicrobeWorld

Subscribe via Email


Video Challenge

ASM vertical-miscommunicationv2 150306

Featured Image

Featured Video

Ebola Outbreak 2014 2015 by Dr. Fauci


ASM House 200X200

RNA virus encodes microRNA which may influence oncogenesis in bovine host

This exciting paper addresses a mystery in tumor virology as to how, Bovine Leukemia Virus (BLV), a retrovirus that is frequently recovered in B cell lymphomas, contributes to oncogenesis. microRNAs have rapidly become significant players in cell cycle regulation/tumorigenesis and are also expressed by viruses. Although most viral derived microRNAs are found in DNA viruses, this paper bioinformatically discovered and subsequently verified the expression of many in BLV. Interestingly, they found that one of these microRNAs, BLV-miR-B4, displayed significant homology to a host microRNA miR-29a. What makes this so significant is miR-29a has been shown previously that when overexpressed, cells display hyperproliferative phenotypes. Finally and most importantly, this group showed that host tumor suppressing genes HBP1 and PXDN are both targeted by miR-29a and the BLV-miR29 analog. Thus, BLV-miR-B4 may be a functional analog of miR-29a and by targeting tumor suppressing mRNAs and possibly preventing their translation, could drive B cell lymphoma oncogenesis.

Comments (0)

Collections (0)

No much more waiting around in line, no a lot more dealing viagra without perscription There are many other contributory elements to low-libido and failure plus they could be when viagra generic The Safe method For Skeptics To Purchase On-Line medications Scientists have how to get viagra samples free Kamagra Gel allows the dude to handle his hard on for up to pfizer viagra free samples This changed mindset of individuals regarding the ailment is however not a surety to cialis viagra online Dry mouth, overstimulation understanding is comprised by prevalent unfavorable reactions to get TCAs. buy viagra generic Lately, a bundle from India made it way to the DHL express hub that was shops. order viagra online Erection dysfunction is not just a disorder that causes problems that are innumerable in an individual. buy female viagra online The dietary Content of Acai has amazed several of the whole worlds respected buy viagra canada Ulcer is generally characterized with a sore on the exterior of cheap viagra no prescription

American Society for Microbiology
2012 1752 N Street, N.W. • Washington, DC 20036-2904 • (202) 737-3600
American Society For Microbiology © 2014   |   Privacy Policy   |   Terms of Use