MicrobeWorld App

appsquarebannerad200x200

Join MicrobeWorld

Subscribe via Email

subscribe

Microbes After Hours

shutdown

Click for more "Microbes After Hours" videos

Featured Image

Featured Video

Crowdsourced Microbes Heading to Station

Supporters

ASM House 200X200

USA300 strain of S. aureus

Staph_2010-08-26.jpg
The USA300 strain of Staphylococcus aureus bacteria, colorized in gold, shown outside a white blood cell.

Staphylococcus aureus: USA:300 is a strain of gram-positive coccus bacteria responsible for Methicillin-resistant Staphylococcus aureus (MRSA), or Staph infection in humans. This strain of S. aureus is resistant to β-lactam antibiotics. When cultured, this bacteria appears as golden clusters. The golden color is the result of a carotenoid pigment that protects the bacteria against host-immune system reactive oxygen species, and adds to the bacteria's virulence. S. aureus is a facultative anerobe, which can be found in a wide variety of locations such as soil, human skin, and public places like hospitals and prisons. This strain of S. aureus: USA 300 was first identified in 1998, and is thought to be the primary causal strain of community-acquired Staph infections throughout the United States, Canada and Europe. In 2006 the CDC reported that 64% of MRSA isolated from infected patients were of the USA 300 strain. This bacteria contains the cytotoxin Panton-Valentine leukocidin (PVL), which targets leukocytes. It also contains modulin, which is a phenol-soluble peptide (PSM) that is capable of lysing neutrophilic granulocytes. These toxins cause rapidly-progressing fatal conditions such as necrotizing pneumonia and faciitis and severe sepsis. USA:300 causes an estimated 20-40 thousands deaths annually and worldwide.

Photo Credit: RML/NIAID
Content Credit: http://microbewiki.kenyon.edu
 
 

Comments (0)

Collections (1)

 

American Society for Microbiology
2012 1752 N Street, N.W. • Washington, DC 20036-2904 • (202) 737-3600

Copyright © American Center for Microbiology 2012. All Rights Reserved.