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Build a better antibody to neutralize HIV

Biologists have built a better antibody in an effort to neutralize the many subtypes of HIV. The work builds on earlier efforts that involved using highly potent antibodies isolated from HIV-positive people. Now, a team from the California Institute of Technology (Caltech) has used one of these naturally occurring antibodies to create a stronger version—one the researchers believe is a better candidate for clinical applications.

Current advances in isolating antibodies from HIV-infected individuals have allowed for the discovery of a large number of new, broadly neutralizing anti-HIV antibodies directed against the host receptor (CD4) binding site—a functional site on the surface of the virus that allows for cell entry and infection.

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