MicrobeWorld App

appsquarebannerad200x200

Join MicrobeWorld

Subscribe via Email

subscribe

Microbes After Hours

MW-Site-Banner-200x200

Click for more "Microbes After Hours" videos

Featured Image

Featured Video

Crowdsourced Microbes Heading to Station

Supporters

ASM House 200X200

Research Yields Unprecedented Insight Into Antiviral Immune Response

Image
Many viruses infecting humans including influenza virus, hepatitis C virus, West Nile virus, rabies and measles viruses contain a ribonucleic acid (RNA) genome. These viruses are dependent on RNA as genetic information and they duplicate in human cells to make copies, thereby infecting other cells and spreading the virus. Researchers from UMDNJ-Robert Wood Johnson Medical School and Rutgers, The State University of New Jersey, led by principal investigators Joseph Marcotrigiano and Smita Patel, show, for the first time, the structure of retinoic-acid-inducible gene-I, or RIG-I. RIG-I is a human protein that detects whether the RNA comes from a virus (viral RNA) and, if so, initiates an auto-immune response. Isolating the structure of RIG-I with RNA bound is the first step in developing broad-based therapies against viral infections.

The study, "Structural basis of RNA recognition and activation by innate immune receptor RIG-I," was chosen for advanced online publication in Nature on September 25, 2011. (http://www.nature.com/nature/journal/vaop/ncurrent/abs/nature10537.html)
 
 

Comments (0)

Collections (0)

 

American Society for Microbiology
2012 1752 N Street, N.W. • Washington, DC 20036-2904 • (202) 737-3600
American Society For Microbiology © 2014   |   Privacy Policy   |   Terms of Use