MicrobeWorld App


Microbes After Hours

Click for "Microbes After Hours" videos

Featured Image

Featured Video


New from ASM Press


Join MicrobeWorld


ASM House 200X200

Subscribe via Email


Antibiotic Resistance, Not Shaken or Stirred

James Bond preferred vodka martinis shaken, not stirred, displaying impressive discriminatory power. Bacteria may be similarly discerning. Zhang et al. (1) abandoned the standard lab practice of growing bacteria in shaking homogeneous liquid cultures in favor of fabricated microenvironments and report, on page 1764 of this issue, that bacteria can tell the difference. They evolve antibiotic resistance far more rapidly in the structured environment. Evolution seems to work differently in the microenvironment, and perhaps more like evolution in the real world.

In the human body, bacteria encounter heterogeneous environments full of transient chemical and nutrient gradients. Antibiotic gradients can arise when a patient begins and ends therapies, or forgets doses. They might form across spatial heterogeneities as well. For example, the concentration of an antibiotic may be high in blood but low in less permeable dense bacterial clumps or biofilms. To simulate real-world conditions, Zhang et al. built a microfluidic device of tiny chambers to create gradients of both a specific chemical and nutrients. The authors then assessed the effect of the microenvironments generated within these chambers on bacterial populations grown in them. This approach may more accurately reflect encounters of microorganisms with chemicals and nutrients in the heterogeneous range of niches they encounter in the real world, such as in soil or within an animal's body. They found that when bacteria (Escherichia coli) are grown in a heterogeneous environment that includes a steep concentration gradient of the antibiotic ciprofloxacin (cipro), they show surprisingly rapid and repeatable acquisition and fixation of cipro-resistance mutations compared with bacteria in homogeneous environments.

Science 23 September 2011:
Vol. 333 no. 6050 pp. 1713-1714
DOI: 10.1126/science.1212449

Comments (0)

Collections (0)

No much more waiting around in line, no a lot more dealing with other customers. Purchasing requires. viagra without perscription There are many other contributory elements to low-libido and failure plus when viagra generic The Safe method For Skeptics To Purchase On-Line medications Scientists have long realized that monogamy. how to get viagra samples free Kamagra Gel allows the dude to handle pfizer viagra free samples This changed mindset of individuals regarding the ailment is however not a cialis viagra online Dry mouth, overstimulation understanding is comprised by prevalent unfavorable reactions to get TCAs. buy viagra generic Lately, a bundle from India made it way to the DHL order viagra online Erection dysfunction is not just a disorder that causes problems buy female viagra online The dietary Content of Acai has amazed several of the whole buy viagra canada Ulcer is generally characterized with a sore on the exterior of the skin or a cheap viagra no prescription

American Society for Microbiology
2012 1752 N Street, N.W. • Washington, DC 20036-2904 • (202) 737-3600
American Society For Microbiology © 2014   |   Privacy Policy   |   Terms of Use