Recently, Yale’s Richard Flavell led a team of researchers into the most talked about and yet one of the least understood of microbial environments—the human gut. Rather than present the usual metagenomic characterization of the microbial population, he teamed up with Jeff Gordon at Washington University in Saint Louis and others to investigate one of the most important questions in the field: how does the host organism detect and respond to the replacement of its ‘normal’ gut bacteria with ‘abnormal?’
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