Jennifer Ross built a microscope she calls Single Molecule TIRF, for total internal reflection fluorescence, that is much brighter than commercially available instruments and has the remarkable ability to see and photograph single molecules in real time.
An image from the TIRF instrument from one of Ross and colleagues’ recent studies of the enzyme katanin was recently featured on the cover of Biophysical Journal, accompanying their article reporting that they have for the first time seen and recorded video of an enzyme cutting microtubules. This accomplishment is a key to understanding basic microtubule function and what goes wrong in diseases related to their malfunction.
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