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Meningitis: Neisseria Meningitidis Disseminates Itself by Sending out 'Scouts'

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Although, in the majority of cases, the localized presence of Neisseria meningitidis in the throat has no consequence, it can sometimes lead to meningitis or septicaemia. The seriousness of these two infections is driving researchers from around the world to improve their understanding of the mode of operation of this bacterium, which, once it leaves its favourite location (the throat) becomes extremely dangerous.

The Avenir team directed by Guillaume Duménil within Inserm Mixed Research Unit 970, "Paris centre de recherche cardiovasculaire" at the Université Paris Descartes, has recently discovered how this bacterium disseminates, leaving the throat to pass into the bloodstream.

The results of this research have been published in the 11 February 2011 issue of the journal Science.

Neisseria meningitidis is a bacterium specific to man. It is frequently present in the non-pathogenic state in the throat of healthy carriers (5% to 30% of the population).

Its persistence in the organism can however prove dangerous in some cases. The location where the bacteria multiply, the throat, represents a port of entry, from where it disseminates into the bloodstream and may penetrate into the brain. In both these cases, the infection becomes very serious since it results in septicaemia or meningitis. Unless dealt with quickly, the mortality rate linked to these two infections is very high.

Guillaume Duménil and his Inserm research team were, therefore, interested to understand more about this bacterium which, when it passes into the bloodstream, becomes very dangerous. "Certain advances made in the past few years provided the starting point for this work, which is published in Science", he explained. We know, for example, that Neisseria meningitidis are equipped with special structures known as pili. These allow the bacteria to adhere to the cells of the throat and to multiply and form aggregates there. We are closely studying the main protein which makes up the pili; namely, pilin", adds Guillaume Duménil.

The researchers then discovered that the protein underwent various modifications over time. One of these, in particular, has proved more interesting than the others: The addition of a phosphoglycerol. This chemical group once grafted onto the pilin, gives the signal for dissemination.
 
 

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