MicrobeWorld App

appsquarebannerad200x200

Microbes After Hours

MWbannerEbola

Click for more "Microbes After Hours" videos

Join MicrobeWorld

Subscribe via Email

subscribe

Featured Image

Featured Video

Oldest-life-on-earth

Supporters

ASM House 200X200

Warning: imagecreatefromstring(): Data is not in a recognized format in /var/www/plugins/content/jlembed/jlembed.php on line 253 Warning: imagesx(): supplied argument is not a valid Image resource in /var/www/plugins/content/jlembed/jlembed.php on line 254 Warning: imagedestroy(): supplied argument is not a valid Image resource in /var/www/plugins/content/jlembed/jlembed.php on line 255

Defense Mechanism Against Bacteria and Fungi Deciphered

To defend microbial attacks, the human body naturally produces a group of antibiotics, called defensins. An interdisciplinary team of biochemists and medical scientists has now deciphered the mechanism of action of a defensin, hitherto looked upon as exhibiting only minor activity. Their results might be useful in future drug development for inflammatory and infectious diseases. Nature now presents their findings online ahead of the print publication.

Under standard laboratory conditions, the human beta-defensin 1 (hBD-1), a human antibiotic naturally produced in the body, had always shown only little activity against microbes. Nevertheless the human body produces it in remarkable quantities. The solution to the puzzle was the investigation process itself, as the research group led by Dr. Jan Wehkamp at the Dr. Margarete Fischer-Bosch Institute for Clinical Pharmacology of the Stuttgart-based Robert Bosch Hospital found out.

Before the research group took a new approach to this research, defensins were usually tested in the presence of oxygen, although little oxygen is present, for example, in the human intestine. Starting out from the discovery that a special antibiotic-activating protein of the human body is diminished in patients with inflammatory bowel diseases, Crohn's Disease and Ulcerative Colitis, the working group investigated how defensins act under low-oxygen conditions. During their investigations the scientists found out that under these conditions hBD-1 unfolds a strong antibiotic activity against lactic acid bacteria and yeast.
 
 

Comments (0)

Collections (0)

 
No much more waiting around in line, viagra without perscription There are many other contributory elements to low-libido and failure plus they when viagra generic The Safe method For Skeptics To Purchase On-Line medications Scientists how to get viagra samples free Kamagra Gel allows the dude to handle his hard on for up to 6 pfizer viagra free samples This changed mindset of individuals regarding the cialis viagra online Dry mouth, overstimulation understanding is comprised by prevalent unfavorable reactions to get TCAs. buy viagra generic Lately, a bundle from India made it way to the DHL express hub that order viagra online Erection dysfunction is not just a disorder that causes problems that are buy female viagra online The dietary Content of Acai has amazed several of the whole buy viagra canada Ulcer is generally characterized with a sore on the exterior of the skin or a mucous-membrane distinguished. cheap viagra no prescription

American Society for Microbiology
2012 1752 N Street, N.W. • Washington, DC 20036-2904 • (202) 737-3600
American Society For Microbiology © 2014   |   Privacy Policy   |   Terms of Use