MicrobeWorld App

appsquarebannerad200x200

Microbes After Hours

microbes-after-hours-logo
Click for "Microbes After Hours" videos

Agar Art Contest 2016

AgarArt-MicrobeWorld-200x200

Featured Image

Featured Video

MWV102featured

Join MicrobeWorld

Supporters

ASM House 200X200

Subscribe via Email

subscribe

From unpleasant infection to flesh-eater: Three virulence factors help Group A Strep make the switch

Image
Group A Streptococcus (GAS) is responsible for infections ranging from “strep throat” to necrotizing fasciitis, aka the “flesh-eating disease”, a severe and invasive condition that has seen a marked increase in incidence in the past 30 years. The increase has been pinned on a single clone of the M1T1 serotype, which undergoes a genetic “switch” in the body to a hypervirulent state that allows it to move into the bloodstream.

In a study just released by mBio, researchers identify the virulence factors GAS needs to make the switch. Only three factors are needed: nuclease Sda1, M1 protein, and hyaluronic acid capsule together comprise a quorum of cooperative virulence factors that promote resistance to traps set by the immune system.
 
 

Comments (0)

Collections (0)

 

American Society for Microbiology
2012 1752 N Street, N.W. • Washington, DC 20036-2904 • (202) 737-3600
American Society For Microbiology © 2014   |   Privacy Policy   |   Terms of Use