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Disrupting Quorum Sensing

An interesting article on the challenges facing researchers who are developing the second generation of antibiotics. "Quorum sensing is now known to be widespread in the bacterial world, and many researchers hope to develop ways to disrupt it. Kim Janda, a chemical biologist at the Scripps Research Institute in La Jolla, Calif., calls this strategy a “stealth approach.” Antibiotics kill bacteria or prevent them from growing, enabling resistant mutants to thrive; drugs that disrupt quorum sensing, on the other hand, would spare the microbes’ lives, simply preventing them from causing disease or building biofilms.

The problem is that good quorum-sensing inhibitors have been hard to find. "

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