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Split-Virus Vaccine Better of Two H1N1 Shots

Of the two vaccines used in the U.K. to protect against pandemic H1N1 influenza, the adjuvanted split-virus vaccine offered better protection for children than the non-adjuvanted whole-virus vaccine, but caused more side effects, a phase II study showed.

After two doses, there were higher seroconversion rates with the adjuvanted vaccine both in children younger than 3 (98.2% versus 80.1%, Pimmunogenicity of the adjuvanted split-virion vaccine in the youngest children in our study suggests that novel adjuvants could be used to improve the immunogenicity of seasonal influenza vaccines in this population."

Children have been heavily affected by the H1N1 pandemic and were in the priority group for vaccination in most countries. But there is little safety and efficacy data for the new vaccines.

Waddington and her colleagues compared the two pandemic vaccines purchased by the U.K. Department of Health, GlaxoSmithKline's AS03B adjuvanted split-virus vaccine derived from egg culture, which contains 1.875 µg of haemagglutinin antigen, and Baxter's non-adjuvanted whole-virus vaccine derived from cell culture, which contains 7.5 µg of haemagglutinin.
 
 

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