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Microbicides That Do More Than Gel: Vaginal Rings, Tablets and Films

A flexible ring containing two anti-HIV drugs showed in laboratory tests that it can deliver therapeutic levels of both drugs for up to 30 days, researchers reported at the International Microbicides Conference (M2010) in Pittsburgh, adding that they consider the ring near ready for testing of its safety in women.

Vaginal rings have been used to deliver contraceptives and now this strategy is being applied for delivering formulations of microbicides to protect against HIV. Unlike gels that must be used every day or at the time of sex, rings can be inserted into the vagina and stay in for a month or longer. And, for certain drugs or drug combinations, these formulations may be the more optimal vehicles for delivery.

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