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Bad company: Mixed Infections of Cryptococcus neoformans

Bad company: Cryptococcus neoformans is responsible for an estimated 1 million cases of cryptococcal disease every year, predominantly meningoencephalitis. These cases are often fatal. So, what’s worse than an infection with one kind of Cryptococcus? A new paper selected for the inaugural issue of mBio shows many cases we thought were caused by a single type of C. neoformans may actually be caused by more than one mating-type, serotype and/or genotype. This could explain why antibiotic treatments for cryptococcal disease often fail even after clinical isolates proved to be susceptible. And Cryptococcus neoformans is probably not an isolated case; clinicians may have to reconsider their assumptions about the one organism/one infection model in regard to a number of other diseases as well.

The unrevised version of Desnos-Ollivier et al. is available on the mBio website now. A final, typeset version of the article will appear in the inaugural issue of the online journal in May.

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