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Two novel ways to kill TB discovered

Scientists have discovered two novel ways of killing the bacteria that cause tuberculosis (TB).

According to researchers at Albert Einstein College of Medicine of Yeshiva University, their findings could lead to a potent TB therapy that would also prevent resistant TB strains from developing.

"This approach is totally different from the way any other anti-TB drug works. In the past few years, extremely drug resistant strains of TB have arisen that can't be eliminated by any drugs, so new strategies for attacking TB are urgently needed," said William R. Jacobs, Jr., the study's senior author and professor of microbiology and immunology and of genetics at Einstein, as well as a Howard Hughes Medical Institute investigator.

Tuberculosis is caused by the bacterial species Mycobacterium tuberculosis. In searching for a new Achilles' heel for M. tuberculosis, Jacobs and colleagues focused on an enzyme called GlgE.
 
 

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