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Human Genetic Vulnerabilities May Underlie Infectious Diseases, Scientist Argues

Rockefeller University's Jean Laurent Casanova spoke on the connection between genetics and infectious diseases at the 2010 annual conference of the American Association for the Advancement of Science (AAAS) on Friday, February 19, focusing on current findings and putting them in context in this small but emerging field.

The talk, titled "Inborn Errors of Innate Immunity in Humans," was presented at AAAS's symposium on innate immunity at 1:50 p.m. in Room 5A at the San Diego Convention Center.

Drawing from his most recent work on invasive pneumococcal disease and herpes simplex encephalitis, Casanova presented evidence that infectious diseases in the general population depend to a large extent on underlying genetic vulnerabilities. While microbes are required for infection, he says, one's genetic background could make the difference between fighting an infection and succumbing to it.

"Individual patients lacking one or another molecular component of innate immunity are highly vulnerable to a narrow range of microbes," says Casanova. "We try to describe individual mutations and specific components in innate immunity that either confer resistance or susceptibility to a specific microbe or genus."
 
 

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