How do one-celled parasites move from the salivary gland of a mosquito through a person's skin into red blood cells? What molecular mechanisms form the basis for this very important movement of the protozoa? A team of researchers headed by Dr. Friedrich Frischknecht, head of a research group at the Department of Infectious Diseases at Heidelberg University Hospital, observed the initial stage of the malaria parasite that is transmitted by mosquitoes with new microscope techniques. They discovered that the parasite continually alternates between phases of rapid gliding and phases of firm adhesion to the surface. The interaction of these two processes probably enables the parasite to move rapidly over a long time, which is necessary for successful transmission of the disease. The research was a colaboration within the CellNetworks cluster of excellence and published in the prestigious journal Cell Host & Microbe.