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Tamiflu-Resistant H1N1 Flu Infects Seven on Vietnamese Train

A cluster of seven people infected with a Tamiflu-resistant strain of pandemic H1N1 influenza has been identified by researchers in Vietnam and reported in the New England Journal of Medicine.

The cases show the ability of Tamiflu-resistant pandemic H1N1 to spread among healthy people who are not taking the antiviral drug, say the scientists from Vietnam's National Institute of Hygiene and Epidemiology and Oxford University's Clinical Research Unit in Vietnam.

All seven cases were passengers on the same 42 hour train journey in Vietnam, who were taken ill within a couple of days of completing their journeys. Six were from a group of 10 students who met and socialized with each other in the same carriage. The seventh case was a passenger in a separate carriage.

Six of the cases were admitted to hospital for isolation while the seventh was isolated at home. All were treated twice daily with the recommended 75 mg dose of Tamiflu. All of the patients made a full recovery despite the resistance.

(Editor's note - there's a MicrobeWorld Video episode about this sort of transmission; http://www.microbeworld.org/index.php?option=com_content&view=article&id=219:modern-transportation-a-infectious-disease&catid=36:microbeworld-video&Itemid=146)
 
 

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