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Starving Dengue Fever Virus of Critical Building Blocks

New research shows that cutting down the amount of fat particles in cells may be an effective way to prevent the dengue fever virus from replicating and spreading.

Howard Hughes Medical Institute international research scholar Andrea V. Gamarnik and her colleagues have shown that the dengue virus hijacks fat droplets inside cells and uses those tiny fat globules to build new infectious virus particles. The scientists have been able to slow down dengue virus assembly in a Petri dish using experimental obesity drugs that deplete cells of fat droplets. The approach prevents the virus from having access to critical building blocks, a strategy that they hope will prove useful in combating the debilitating and sometimes-deadly disease.

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