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Researchers Identify Workings of L-Form Bacteria

Researchers at the Johns Hopkins Bloomberg School of Public Health have for the first time identified the genetic mechanisms involved in the formation and survival of L-form bacteria. Their findings are described in a study published October 6 in the journal PLoS ONE.

L-form bacteria, which were first discovered in the 1930s, are morphological variants of classical bacteria that lack a cell wall. Under specialized growth conditions L-form bacteria are capable of forming a typical “fried egg” colony, which resembles a fried egg rather than the smooth appearance of a classic bacteria colony.

These bacteria are believed to form in response to cell wall stress from certain antibiotics or the body’s immune attack, and are suspected to be associated with antibiotic-resistant and persistent infections, as well as certain diseases.
 
 

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