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Microscopy Meets Photography, 200 Years Later

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Robert Koch published the first photographs of individual bacteria in 1877, nearly 200 years after Antoni van Leeuwenhoek sent drawings of bacteria in a letter to the Royal Society. Long before cameras were linked with microscopes, generations of microscopists relied on their own eyes, pencil, and paper to record what microbes looked like and what they were doing. What happened during that centuries-long lag period between hand-drawn illustrations of microbes and the true-to-life images that biologists are used to today?

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