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Taking Sharper Aim at Stomach Ulcer Bacteria

Scientists are reporting discovery of a much sought after crack in the armor of a common microbe that infects the stomachs of one-sixth of the world’s population, causing stomach ulcers and other diseases. They identified a group of substances that block a key chemical pathway that the bacteria need for survival. Their study, which could lead to new, more effective antibiotics to fight these hard-to-treat microbes, is scheduled for the Oct. 16 issue of the journal ACS Chemical Biology.

Javier Sancho, PhD, and colleagues note in the new study, “Discovery of specific flavodoxin inhibitors as potential therapeutic agents against Helicobacter pylori infection,” that Helicobacter pylori ( H. pylori ) bacteria infect the stomach lining and can cause gastritis and ulcers. Treatment with broad-spectrum antibiotics can cure H. pylori infections. However, an estimated one billion people remain infected worldwide because of the cost of existing antibiotics and the emergence of antibiotic resistant strains of the bacteria, the researchers say.

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