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Nitric Oxide May Be Key to Overcoming Antibiotic Resistance

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A new study, co-authored by Evgeny Nudler, professor of biochemistry at New York University Langone Medical Center in Manhattan, and published online yesterday in Science, shows that stopping the creation of bacterial nitric oxide synthases (bNOS), enzymes that contribute to the production of NO, may leave microbial pathogens more vulnerable to antibiotic treatment.

If researchers could adapt NOS inhibitors, which are already commercially available, to be safe and effective in antibiotic treatments, even the toughest MRSA or Bacillus anthracis strains (which cause anthrax) might not be able to stand up to a drug's oxidative stress load.

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