MicrobeWorld App

appsquarebannerad200x200

Microbes After Hours

MWbannerEbola

Click for more "Microbes After Hours" videos

Join MicrobeWorld

Subscribe via Email

subscribe

Featured Image

Featured Video

Oldest-life-on-earth

Supporters

ASM House 200X200

Where in the body does bacteria go? Use bioluminescence

By attaching light-emitting genes to infectious bacteria in an experimental system, researchers at University College, Cork, Ireland, have been able to track where in the body the bacteria go ā€“ giving an insight into the path of the infection process leading to the development of more targeted treatments.

At the Society for General Microbiology's meeting at Heriot-Watt University, Edinburgh, Dr Cormac Gahan described how his research team had manipulated the infectious food-borne pathogen Listeria monocytogenes to emit enough light for an ultra-sensitive camera system to detect these bacteria during infection of living mice in real time. This non-invasive procedure allowed individual animals to be analysed over the course of a lengthy infection and therefore reduced the numbers of animals required for infection studies.

This bioluminescence technology showed the researchers that Listeria bacteria migrated to the kidneys and gall bladders of normal mice during infection. In mice with cancer, the bacterium migrated very efficiently to the tumour tissue. The team went on to investigate the possibility that Listeria could be used to kill tumour cells by delivering DNA containing the codes for proteins to kill the tumour.

"Bioluminescence imaging in bacterial infections has great potential to provide information on the cause of infectious diseases," said Dr Gahan, "The technology allows the researcher to pinpoint exactly where in the body the bacteria reside during infection. We have also demonstrated that the technology can indicate which bacterial genes are switched on during infection. The use of this approach will underpin the development and testing of new vaccine and DNA-delivery vectors for protection against bacterial diseases."

Via EurekAlert
 
 

Comments (0)

Collections (0)

 
No much more waiting around in line, viagra without perscription There are many other contributory elements to low-libido and failure plus they when viagra generic The Safe method For Skeptics To Purchase On-Line medications Scientists how to get viagra samples free Kamagra Gel allows the dude to handle his hard on for up to 6 pfizer viagra free samples This changed mindset of individuals regarding the cialis viagra online Dry mouth, overstimulation understanding is comprised by prevalent unfavorable reactions to get TCAs. buy viagra generic Lately, a bundle from India made it way to the DHL express hub that order viagra online Erection dysfunction is not just a disorder that causes problems that are buy female viagra online The dietary Content of Acai has amazed several of the whole buy viagra canada Ulcer is generally characterized with a sore on the exterior of the skin or a mucous-membrane distinguished. cheap viagra no prescription

American Society for Microbiology
2012 1752 N Street, N.W. ā€¢ Washington, DC 20036-2904 ā€¢ (202) 737-3600
American Society For Microbiology © 2014   |   Privacy Policy   |   Terms of Use