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Activation of a Macrophage by an Effector T Lymphocyte

Major histocompatibility (MHC) molecules enable T lymphocytes to recognize epitopes of antigens and discriminate self from nonself. Unlike B-cell receptors on B lymphocytes that are able to directly bind epitopes on antigens, the T-cell receptors (TCRs) of T lymphocytes can only recognize epitopes, typically short chains of amino acids called peptides, after they are bound to MHC molecules. There are two classes of MHC molecules: MHC-I and MHC-II. MHC-I presents epitopes to CD8 (T8) lymphocytes while MHC-II presents epitopes to CD4 (T4) lymphocytes.

This is a two part animation. In the first animation in this series, a macrophage is shown processing an exogenous antigen for eventual presentation to a Th1 lymphocyte. In the second animation in this series, the activation of a macrophage by a Th1 lymphocyte is shown.

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