MicrobeWorld App

appsquarebannerad200x200

Microbes After Hours

MWbannerEbola

Click for more "Microbes After Hours" videos

Join MicrobeWorld

Subscribe via Email

subscribe

Featured Image

Featured Video

Oldest-life-on-earth

Supporters

ASM House 200X200

Endogenous RNA virus inhibits Borna disease virus replication

Image
Animal genomes are known to contain captured retroviruses, typically referred to as endogenous retroviruses (ERVs). Many of these elements are still transcribed and are known to be involved in both beneficial functions in animal biology, such as placenta formation, and not-so beneficial functions such as certain auto-immune diseases as well as cancer. Interestingly, in some cases, such as in ERVs from sheep, they actually protect their hosts from exogenous (incoming) retroviruses.
However, it is not often mentioned that Bornaviruses, non-segmented RNA viruses that replicate in the nuclei of their hosts, have also been shown to be endogenous viruses in several mammalian host genomes including humans, non-human primates, rodents and elephants. This is especially interesting given that these viruses do not integrate into their host genomes as a part of their normal replication cycle. This implies that at some point in mammalian evolution, a bornavirus relative relied on a host-derived mechanism, probably retrotransposons, for its capture and subsequent endogenization. The portion of the endogenous bornavirus (EnBVs) genome predominantly encodes the viral nucleocapsid. Previous studies have found that the bornavirus nucleocapsid protects cells from subsequent bornavirus infections.
In this study, the authors cloned sequences from an endogenous bornavirus of squirrels into a cell line, and monitored both its solitary activity and how it interacts with an exogenous bornavirus. They found that this transcript encoded a protein that co-localized within the viral replication factory of the exogenous bornavirus in the nucleus. Not only did this protein result in a reduced level of replication of the introduced bornavirus, but cells stably expressing the EnBV protein were completely resistant to exogenous bornaviruses. They then went on to show that the protein "appeared to affect BDV polymerase activity by being incorporated into the viral ribonucleoprotein". Interestingly, the human version of the EnBV did not have this same effect.
 
 

Comments (0)

Collections (0)

 
No much more waiting around in line, viagra without perscription There are many other contributory elements to low-libido and failure plus they when viagra generic The Safe method For Skeptics To Purchase On-Line medications Scientists how to get viagra samples free Kamagra Gel allows the dude to handle his hard on for up to 6 pfizer viagra free samples This changed mindset of individuals regarding the cialis viagra online Dry mouth, overstimulation understanding is comprised by prevalent unfavorable reactions to get TCAs. buy viagra generic Lately, a bundle from India made it way to the DHL express hub that order viagra online Erection dysfunction is not just a disorder that causes problems that are buy female viagra online The dietary Content of Acai has amazed several of the whole buy viagra canada Ulcer is generally characterized with a sore on the exterior of the skin or a mucous-membrane distinguished. cheap viagra no prescription

American Society for Microbiology
2012 1752 N Street, N.W. • Washington, DC 20036-2904 • (202) 737-3600
American Society For Microbiology © 2014   |   Privacy Policy   |   Terms of Use