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More than glitter: Scientists explain how gold nanoparticles easily penetrate cells, making them useful for delivering drugs

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A special class of tiny gold particles can easily slip through cell membranes, making them good candidates to deliver drugs directly to target cells.

A new study from MIT materials scientists reveals that these nanoparticles enter cells by taking advantage of a route normally used in vesicle-vesicle fusion, a crucial process that allows signal transmission between neurons. In the July 21 issue of Nature Communications, the researchers describe in detail the mechanism by which these nanoparticles are able to fuse with a membrane.

The findings suggest possible strategies for designing nanoparticles — made from gold or other materials — that could get into cells even more easily.

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