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Slaying bacteria with their own weapons

A chemist at Washington University in St. Louis is studying siderophores, iron chelating molecules released by bacteria during an infection, with the thought of using them to design personalized antibiotic therapy that would avoid the rapid evolution of resistance that plagues antibiotic drug discovery. The siderophores, he thinks, can be used both as a diagnostic, to rapidly identify the pathogen, and as a therapeutic, to trick the pathogen into pumping antibiotics inside their cell membranes.

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