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UEA researchers discover Achilles’ heel in antibiotic-resistant bacteria

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Scientists at the University of East Anglia have made a breakthrough in the race to solve antibiotic resistance.

New research published today in the journal Nature reveals an Achilles’ heel in the defensive barrier which surrounds drug-resistant bacterial cells.

The findings pave the way for a new wave of drugs that kill superbugs by bringing down their defensive walls rather than attacking the bacteria itself. It means that in future, bacteria may not develop drug-resistance at all.

The discovery doesn’t come a moment too soon. The World Health Organization has warned that antibiotic-resistance in bacteria is spreading globally, causing severe consequences. And even common infections which have been treatable for decades can once again kill.

Researchers investigated a class of bacteria called ‘Gram-negative bacteria’ which is particularly resistant to antibiotics because of its cells’ impermeable lipid-based outer membrane.

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