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Study Finds Cervicovaginal Microbiota Different in Women Destined to Have Preterm Birth

In a study to be presented on Feb. 6 at 3:15 p.m. CST, at the Society for Maternal-Fetal Medicine’s annual meeting, The Pregnancy Meeting ™, in New Orleans, researchers will report that cervicovaginal (CV) microbiota differs in the late second and early third trimester in women destined to have a preterm birth.

The study tested vaginal swabs from pregnant women in the late second trimester (20-24 weeks) and early third trimester (24-28) weeks of pregnancy, and compared the CV biospecimens of women who ultimately had a preterm birth to those who had a term birth.

Using DNA obtained on those swabs, the microbial communities were characterized by community state types (CSTs) using state-of-the-art technology. CST I are dominated by Lactobacillus crispatus, traditionally considered a beneficial bacteria. CST III are dominated by Lactobacillus iners, and CST IV are dominated by anaerobic bacteria normally considered to contribute to the condition of bacterial vaginosis.

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