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Gene prevents buildup of misfolded cell proteins

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Much like how a snowplow is needed to clear streets of heavy snow, cells employ a set of genes to clear away misfolded proteins, to prevent them from accumulating and destroying the cell.

For the first time, Cornell researchers have demonstrated how a gene called SEL1L plays a critical role in clearing away misfolded proteins. Complications from misfolded proteins lead to cell death and underlie numerous diseases, including Type 1 diabetes and cystic fibrosis.

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