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New Drugs Use Cell "Garbage Disposal" to Kill Bacteria

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A new class of molecules called acyldepsipeptides—ADEPs—may provide a new way to attack bacteria that have developed resistance to antibiotics.

Researchers have discovered a way to increase the potency of ADEPs by up to 1,200 times. Their findings appear in the Journal of the American Chemical Society.

As concerns about bacterial resistance to antibiotics grow, researchers are racing to find new kinds of drugs to replace ones that are no longer effective. ADEPs kill bacteria in a way that no marketed antibacterial drug does—by altering the pathway through which cells rid themselves of harmful proteins.

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