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UNC research demonstrates “guided missile” strategy to kill hidden HIV

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Researchers at the UNC School of Medicine have deployed a potential new weapon against HIV – a combination therapy that targets HIV-infected cells that standard therapies cannot kill.

Using mouse models that have immune systems composed of human cells, researchers led by J. Victor Garcia, PhD, found that an antibody combined with a bacterial toxin can penetrate HIV-infected cells and kill them even though standard antiretroviral therapy, also known as ART, had no effect. Killing these persistent, HIV-infected cells is a major impediment to curing patients of HIV.

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