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Vaccine study reveals link between immunity and cells' starvation response

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Scientists at Emory Vaccine Center have found a link between immunity induced by vaccination and an ancient way that cells adapt to scarcity, a link that could help researchers develop vaccines against challenging infections such as HIV or malaria.

Researchers studying immune responses to the yellow fever vaccine ā€“ one of the most effective in history -- identified a gene whose activation in key immune cells is a sign of a robust response. The gene, called GCN2, encodes a protein involved in sensing amino acid starvation and regulates the process of autophagy, a response to starvation or stress within cells.

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