Colorectal cancer patients have fewer beneficial gut bacteria and more harmful microbes than those without the disease, researchers from the New York University School of Medicine report in Friday’s edition of the Journal of the National Cancer Institute.
While previous research had suggested that gut microbiota played a role in colorectal cancer (CRC), this study is the first to compare samples from both case and control subjects while also considering for potential confounding factors, the researchers said in a statement. The study is reportedly among the largest epidemiological surveys of human gut bacteria and colorectal cancer conducted to date.
Dr. Jiyoung Ahn of the NYU School of Medicine’s Department of Population Health and the NYU Lagone Medical Center, and colleagues analyzed data and samples from 47 case subjects and 94 control subjects participating in a case-control study. The control subjects were gender and body mass index matches for the case subjects, and DNA was extracted from the fecal samples of all participants.